Fenofibratum [Inn-Latin]

Fenofibratum [Inn-Latin] Brand names, Fenofibratum [Inn-Latin] Analogs

Fenofibratum [Inn-Latin] Brand Names Mixture

No information avaliable

Fenofibratum [Inn-Latin] Chemical_Formula

C₂₀H₂₁ClO₄

Fenofibratum [Inn-Latin] RX_link

http://www.rxlist.com/cgi/generic3/fenofibrate.htm

Fenofibratum [Inn-Latin] fda sheet

Fenofibratum_[Inn-Latin] FDA

Fenofibratum [Inn-Latin] msds (material safety sheet)

Fenofibratum_[Inn-Latin] MSDS

Fenofibratum [Inn-Latin] Synthesis Reference

No information avaliable

Fenofibratum [Inn-Latin] Molecular Weight

360.831 g/mol

Fenofibratum [Inn-Latin] Melting Point

80.5 °C

Fenofibratum [Inn-Latin] H₂O Solubility

0.25mg/ml at 25 °C

Fenofibratum [Inn-Latin] State

Solid

Fenofibratum [Inn-Latin] LogP

5.575

Fenofibratum [Inn-Latin] Dosage Forms

Capsule; Tablet

Fenofibratum [Inn-Latin] Indication

For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Fenofibratum [Inn-Latin] Pharmacology

Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.

Fenofibratum [Inn-Latin] Absorption

Fenofibrate is well absorbed from the gastrointestinal tract. After absorption, fenofibrate is mainly excreted in the urine in the form of metabolites, primarily fenofibric acid and fenofibric acid glucuronide

Fenofibratum [Inn-Latin] side effects and Toxicity

LD₅₀=1600 mg/kg (Oral, in mice); Investigated as a teratogen and reproductive hazard.

Fenofibratum [Inn-Latin] Patient Information